博士

沈国民
2016-09-09 23:33  

沈国民,男,汉族,出生于197912月。1998年考入河南师范大学生科院生物教育专业学习,02年毕业后继续在河南师范范大学徐存拴课题组深造,攻读细胞生物学专业的硕士研究生,主要从事肝再生相关的研究。05年毕业后到河南科技大学医学院遗传教研室任教。08年又考入北京协和医学院基础医学研究所,在张俊武课题组攻读生化和分子生物学专业的博士,主要研究HIF1在肝癌糖脂代谢改变中的作用机制。毕业后到美国南阿拉巴马大学(Universityof South Alabama, Mitchell Cancer Institute从事博士后研究,20129月转入圣路易斯华盛顿大学Washington university inSaint Louis生物物理与分子生化系从事博士后研究,主要研究华法林(warfarin)抑制VKOR的机制。目前主持国家自然科学基金1项,参与2项。发表SCI论文10多篇。

教育经历

2008/08-2011/07,北京协和医学院基础医学研究所,生化与分子生物学国家重点实验室,生化与分子生物学,博士,导师: 张俊武。

2002/09-2005/07,河南师范大学,省部共建细胞分化调控国家重点实验室,细胞生物学,硕士,导师:徐存拴。

1998/09-2002/07,河南师范大学,生命科学学院,生物教育。

研究工作经历

2012/09-至今,圣路易斯华盛顿大学 Washington university in Saint LouisBiophysics and Molecular Biochemistry,博士后

2012/02-2012/08, 美国南阿拉巴马大学University of SouthAlabama, Mitchell Cancer Institute,博士后

2005/07-2008/08, 河南科技大学,基础医学院,医学遗传教研室,讲师

在研课题

主持国家自然科学基金一项:

HIF1 调控SCD1 的机制及其在肝癌中的作用研究(31301076)。

参与国家自然科学基金两项:

解整合素-金属蛋白酶ADAM8在肝细胞癌发生发展中的作用机制研究(81201558)。

心肌营养素对阿尔兹海默病转基因模型小鼠脑组织能量代谢的作用及机制研究(U1304806

发表期刊论文

1. Guomin Shen, Ning Ning, Xingsheng Zhao, Xi Liu, Guangyu Wang, Tianzhen Wang,Ran Zhao, Dongmei Wang, Pingyuan Gong, Yan Shen, Yongjian Sun, Xiao Zhao, YinjiJin, Weiwei Yang, Yan He, Lei Zhang, Xiaoming Jin, Xiaobo Li. Adiposedifferentiation-related protein (ADRP) is not involved in hypoxia induciblefactor-1(HIF1) induced lipid accumulation under hypoxia. Molecular MedicineReports. 2015 Dec;12(6):8055-61

2. Shixuan Liu, Wei Cheng, RonaldFowle-Grider, Guomin Shen, and Weikai Li. Structures of anintramembrane vitamin K epoxide reductase homolog reveal control mechanisms forelectron transfer. Nature Communication. 2014; 5: 3110. doi: 10.1038/ncomms4110

3. Guomin Shen,Xiaobo Li, Yong-feng Jia, Gary A Piazza, Yaguang Xi. Hypoxia-regulated microRNAs in human cancer. ActaPharmacol Sin. 2013, Mar; 34(3):336-341

4.Guo-Min Shen, Ying-Ze Zhao, Ming-Tai Chen, Feng-LinZhang, Xiao-Ling Liu, Yi Wang, Chang-Zheng Liu, Jia Yu, Jun-Wu Zhang. HypoxiaInducible Facter 1 (HIF1) Promotes LDL and VLDL Uptake Through Inducing VLDLRUnder Hypoxia. Biochem J, 2012, Jan; 441(2):675-683

5. Guo-Min Shen, Feng-Lin Zhang, Xiao-Ling Liu, Jun-WuZhang. Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotesglycogen accumulation in human MCF-7 cells under hypoxia. FEBS Lett.2010, 584(20):4366-4372

6.Feng-Lin Zhang, Guo-Min Shen, Xiao-Ling Liu, Fang Wang, Jun-WuZhang. Hypoxia-inducible factor 1-mediated human GATA1induction promotes erythroid differentiation under hypoxic conditions. J CellMol Med, 2012, Aug; 16(8):1889-1899

7. Feng-Lin Zhang,Guo-Min Shen, Xiao-Ling Liu, Fang Wang, Hua-Lu Zhao, Jia Yu, Jun-Wu Zhang.Hypoxic Induction of Human Erythroid-Specific Delta-Aminolevulinate SynthaseMediated by Hypoxia-Inducible Factor 1. Biochemistry, 2011, 50 (7): 1194–1202

8. Pingyuan Gong, Guomin Shen, She Li, Guoping Zhang,Hongchao Fang, Lin Lei, Peizhe Zhang, Fuchang Zhang. Genetic Variations in COMTand DRD2 Modulate Attentional Bias for Affective Facial Expressions. PLoS One. 2013 Dec 2;8(12):e81446. doi:10.1371/journal.pone.0081446

9. Pingyuan Gong, Shoumin Xi, She Li, GuochangCao, Peizhe Zhang, Guomin Shen, Fuchang Zhang, Yan Shen, and HuaMa. Effect of Val66Met polymorphism in BDNF on attentional bias in anextroverted Chinese Han population. Acta Neurobiol Exp (Wars). 2013;73(2):280-8

10. Pingyuan Gong, Shoumin Xi, Guomin Shen,She Li, Peizhe Zhang, Guochang Cao, Fuchang Zhang, Yan Shen, Tiantian Feng, HuaMa. The effects of DBH, MAOA, and MAOB on attentional biases for facialexpressions. J Mol Neurosci. 2013 Mar;49(3):606-131.

11. Xiao-Ling Liu, Hua-Lu Zhao, Guo-Min Shen,Feng-Lin Zhang, Yan Li, Zhi-Yong Zhou, Jian-Hua Cui,Zi-Yuan Duan, Wei Li, Jun-Wu  Zhang. Analysis of two sequencevariants in peroxisome proliferator-activated receptor gamma gene in a Tibetanpopulation at high altitude and a Han population at low altitude in China. MedSci Monit. 2010 Oct 1;16(10):CR458-463

12. Xiao-Ling Liu, Feng-Lin Zhang, Zhi-Yong Zhou,Hua-Lu Zhao, Guo-Min Shen, Wu-Yun Baohan, Zi-Yuan Duan, Wei Li,Jun-Wu Zhang. Analysis of two sequence variants in peroxisome proliferatoractivated receptor gamma gene in Tajik population at high altitudes and Hanpopulation at low altitudes in China. Mol Biol Rep. 2010 Jan;37(1):179-184

13. Guo-min Shen, Ping-yuan Gong, XiaoZhao, Yan Luo, He-mei Peng, Shou-min Xi. Correlation Between the M235TPolymorphism in AGT and Essential Hypertension. Journal of Henan NormalUniversity(Natural Science) (in Chinese). 2009 37(2).113-116

14. Ping-yuan Gong, Guo-min Shen,He-mei Peng, Yan Luo, Yan Shen, Xiao Zhao. Association of the polymorphisms ofsodium transport related genes with essential hypertension. Chinese Journalof Medical Genetics (in Chinese) . 2009 26(1) . 91-94

15. Xiao Zhao, Guo-Min Shen, Qi Feng,Xiao-Gang Sun, Yan Luo. Cytogenetic studies of 131 patients with primaryamenorrhea (including three novel abnormal karyotypes). HEREDITAS (Beijing)(in Chinese), 2008 30(8): 996―1002

国际会议

1.        GuominShen, HaoZhang, Weidong Cui, Jian-Ke Tie, Wei Huang, Evan Sadler, Darrell Stafford, andWeikai Li. Warfarin inhibits human vitamin K epoxide reductase at apreferred conformational state. Molecular, Structural & ClinicalAspects of Vitamin K - Dependent Proteins. 2015. Invited speaker.

2.        GuominShen, HaoZhang, Weidong Cui, Evan Sadler, Michael Gross and Weikai Li. Warfarin InhibitsVitamin K Epoxide Reductase By Specifically Blocking at a Conformational andRedox State. 56th ASH Annual Meeting and Exposition. 2014. Oral andPoster Abstracts.

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