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李钟杰
2021-05-26 16:08  


职称职务:

副教授 科研(学科)秘书

学科专业:

微生物学

研究方向:

细菌感染及其防治

办 公 室:

医科1-504

电子邮箱:

sui_feng5217@126.com

 

 

教育经历:

 

2010.09-2015.06:武汉大学,生命科学学院,微生物学,博士

2006.09-2010.06:新疆大学,生命科学与技术学院,生物工程,学士

 

工作经历:

 

2015.07-至今:河南科技大学,基础医学院,病原生物学教研室

 

教学情况:

 

《医学微生物学》《医学微生物学实验》

 

奖励及荣誉:

 

1.          2020年校精神文明建设文明教工

2.          2019年度青年教师课堂比赛优秀奖

3.          2018-2019学年教师教学优秀三等奖

4.          2017-2018学年河南科技大学优秀教师

 

 

主持课题项目:

 

1. 药用蛞蝓抗菌肽基因的筛选鉴定与功能机制研究,国家自然科学基金青年科学基金项目,81703475

2. 特异性抗口腔致病菌中药多肽发掘及其应用研究,河南省科技攻关,222102310247

 

研究概述:

 

目前的研究课题主要为基于中药的多肽资源的药用基础研究,病原菌耐药调控的分子机制,抗微生物多肽/抗体/小分子,微生态与感染免疫及癌症。

 

代表性论文/著作:

 

1.          In vitro and in vivo antibacterial activity of a lysine-rich   scorpion peptide derivative. Yaping Yuan, Shasha Li, Zhuoran Zhao, Bo Deng,   Ziyi Li, Xiaoyuan Jing, Wenlu Zhang, Zhongjie Li *. Toxicon, 209   (2022) 1–9. (通讯)

2.          Microbial Pathogenesis-Comparative transcription analysis of   resistant mutants against four different antibiotics in Pseudomonas   aeruginosa. Wenlu Zhang, Yaping Yuan, Shasha Li, Bo Deng, Jiaming Zhang, Zhongjie   Li *. Microbial Pathogenesis, 160 (2021) 105166. (通讯)

3.          The transcriptome analysis of the whole-body of the gastropod   mollusk Limax flavus and screening of putative antimicrobial peptide and   protein genes. Zhongjie Li, Yaping Yuan, Miaomiao Meng, Shasha Li, Bo   Deng, Yong Wang. Genomics, 112 (2020) 3991–3999.

4.          Antibacterial activity of a scorpion-derived peptide and its   derivatives in vitro and in vivo. Zhongjie Li, Yaping Yuan , Shasha Li   , Bo Deng , Yong Wang. Toxicon, 2020. 186: p. 35-41.

5.          De novo transcriptome of the whole-body of the gastropod mollusk   Philomycus bilineatus, a pest with medical potential in China. Zhongjie Li,   Yaping Yuan, Miaomiao Meng, Ping Hu, Yong Wang. Journal of Applied Genetics,   2020. 61(3): p. 439-449.

6.          The transcriptome analysis of Protaetia brevitarsis Lewis   ldarvae. Zhongjie Li*, Miaomiao Meng, Shasha Li, Bo Deng. Plos One,   2019. 14(3).

7.          Therapeutic Potential of a Scorpion Venom-Derived Antimicrobial   Peptide and Its Homologs Against Antibiotic-Resistant Gram-Positive Bacteria.   Gaomin Liu, Fan Yang, Fangfang Li, Zhongjie Li, Yange Lang, Bingzheng   Shen, Yingliang Wu, Wenxin Li, Patrick L Harrison, Peter N Strong, Yingqiu   Xie, Keith Miller, Zhijian Cao. Front Microbiol. 2018. 29;9:1159.

8.  K1K8: an Hp1404-derived   antibacterial peptide. Zhongjie Li, Gaomin Liu, Lanxia Meng, Weiwei   Yu, Xiaobo Xu, Wenxin Li, Yingliang Wu, Zhijian Cao. Appl Microbiol   Biotechnol. 2016. 100(11):5069-77.

 





 

 

 

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